Antimalarial compounds from Rhaphidophora decursiva

Citation
Hj. Zhang et al., Antimalarial compounds from Rhaphidophora decursiva, J NAT PROD, 64(6), 2001, pp. 772-777
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
6
Year of publication
2001
Pages
772 - 777
Database
ISI
SICI code
0163-3864(200106)64:6<772:ACFRD>2.0.ZU;2-H
Abstract
Bioassay-directed fractionation led to the isolation of 14 compounds, six o f which possess antimalarial activity, from the dried leaves and stems of R haphidophora decursiva. Polysyphorin (1) and rhaphide-curperoxin (6) showed strong activities against Plasmodium falciparum. Rhaphidecursinol A (2), r haphidecursinol B (3), grandisin (4), and epigrandisin (5) were less active against the same organism. Among the isolates, rhaphidecursinol A (2) and rhaphidecursinol B (3) were determined to be new neolignans, and rhaphidecu rperoxin (6) is a new benzoperoxide. Known compounds isolated include polys yphorin (1), grandisin (4), epigrandisin (5), (+)-medioresinol, (-)-pinores inol, (-)-syringaresinol, (+)-glaberide I, (+)-dehydrovomifoliol, (-)-lilio lide, (-)-hydroxydihydrobovolide, and N-butylbenzamide, of which compound I appears worthy of further evaluation as an antimalarial agent. Structure e lucidation and identification were accomplished by spectroscopic means incl uding 1D and 2D NMR analyses.