New triterpenoid saponins from the sponge Erylus nobilis

Citation
J. Shin et al., New triterpenoid saponins from the sponge Erylus nobilis, J NAT PROD, 64(6), 2001, pp. 767-771
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
6
Year of publication
2001
Pages
767 - 771
Database
ISI
SICI code
0163-3864(200106)64:6<767:NTSFTS>2.0.ZU;2-#
Abstract
Erylosides G-J (1-4), four new triterpenoid saponins, were isolated from th e sponge Erylus nobilis collected from Jaeju Island, Korea. On the basis of the results of combined chemical and spectral analyses, the structures of the aglycones were determined to be lanostane-based, modified penasterols. The oligosaccharide portions were composed of one unit each of L-arabinose, D-galactose, and 2-N-acetyl-D-glucosamine (1 and 3) or two units of L-arab inose and one unit of 2-N-acetyl-D-glucosamine (2 and 4). These compounds e xhibited moderate cytotoxicty against a human leukemia cell line.