Two new cytotoxic and virucidal trisulfated triterpene glycosides from theantarctic sea cucumber Staurocucumis liouvillei

Citation
Ms. Maier et al., Two new cytotoxic and virucidal trisulfated triterpene glycosides from theantarctic sea cucumber Staurocucumis liouvillei, J NAT PROD, 64(6), 2001, pp. 732-736
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
6
Year of publication
2001
Pages
732 - 736
Database
ISI
SICI code
0163-3864(200106)64:6<732:TNCAVT>2.0.ZU;2-E
Abstract
Two new trisulfated triterpene glycosides, liouvillosides A (1) and B (2), have been isolated ft om the Antarctic sea cucumber Staurocucumis liouville i. Their structures have been elucidated by spectroscopic analysis (NMR and FABMS) and chemical transformations. Liouvillosides A(1) and B (2) are two new examples of a small number of trisulfated triterpene glycosides from s ea cucumbers belonging to the family Cucumariidae. Both glycosides were fou nd to be virucidal against herpes simplex virus type 1 (HSV-1) at concentra tions below 10 mug/mL.