Fourteen new sesquiterpenes of the drimane series dendocarbins A-N (1-14) w
ere obtained from ethanol extracts of the Japanese nudibranch Dendrodoris c
arbunculosa, together with two known compounds, isodrimeninol (15) and 11-e
pivaldiviolide (16). All structures were elucidated mainly from spectral da
ta, and most of these sesquiterpenes were found to exhibit cytotoxicity. In
addition, isodrimeninol (15), the major sesquiterpene of this animal, was
found to have a sharp peppery taste.