Dendocarbins A-N, new drimane sesquiterpenes from the nudibranch Dendrodoris carbunculosa

Authors
Sakio, Y Hirano, YJ Hayashi, M Komiyama, K Ishibashi, M
Citation
Y. Sakio et al., Dendocarbins A-N, new drimane sesquiterpenes from the nudibranch Dendrodoris carbunculosa, J NAT PROD, 64(6), 2001, pp. 726-731
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
6
Year of publication
2001
Pages
726 - 731
Database
ISI
SICI code
0163-3864(200106)64:6<726:DANDSF>2.0.ZU;2-J
Abstract
Fourteen new sesquiterpenes of the drimane series dendocarbins A-N (1-14) w ere obtained from ethanol extracts of the Japanese nudibranch Dendrodoris c arbunculosa, together with two known compounds, isodrimeninol (15) and 11-e pivaldiviolide (16). All structures were elucidated mainly from spectral da ta, and most of these sesquiterpenes were found to exhibit cytotoxicity. In addition, isodrimeninol (15), the major sesquiterpene of this animal, was found to have a sharp peppery taste.