Five new prenylated stilbenes from the root bark of Lonchocarpus chiricanus

Citation
Jr. Ioset et al., Five new prenylated stilbenes from the root bark of Lonchocarpus chiricanus, J NAT PROD, 64(6), 2001, pp. 710-715
Citations number
38
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
6
Year of publication
2001
Pages
710 - 715
Database
ISI
SICI code
0163-3864(200106)64:6<710:FNPSFT>2.0.ZU;2-M
Abstract
Besides the known compounds longistylines C (1), D (2), and 3,5-dimethoxyst ilbene (5), five new prenylated stilbenes, named chiricanines A-E (3, 4, 6- 8), have been isolated from the root bark of Lonchocarpus chiricanus. Their structures were resolved on the basis of spectrometric methods including H -1, C-13, and 2D NMR experiments and mass spectrometry. Compound 3 was the only prenylated stilbene to demonstrate antifungal effects against Cladospo rium cucumerinum. Four of the isolated compounds showed toxic properties ag ainst larvae of the yellow fever-transmitting mosquito Aedes aegypti. Compo und 5 was found to be as potent as rotenone in larvicidal dilution tests.