Five new prenylated stilbenes from the root bark of Lonchocarpus chiricanus

Ioset, JR Marston, A Gupta, MP Hostettmann, K

Jr. Ioset et al., Five new prenylated stilbenes from the root bark of Lonchocarpus chiricanus, J NAT PROD, 64(6), 2001, pp. 710-715

38

INGLESE

Article

Agricultural Chemistry","Pharmacology & Toxicology

JOURNAL OF NATURAL PRODUCTS

0163-3864 → ACNP

64

6

2001

710 - 715

ISI

0163-3864(200106)64:6<710:FNPSFT>2.0.ZU;2-M

Besides the known compounds longistylines C (1), D (2), and 3,5-dimethoxyst ilbene (5), five new prenylated stilbenes, named chiricanines A-E (3, 4, 6- 8), have been isolated from the root bark of Lonchocarpus chiricanus. Their structures were resolved on the basis of spectrometric methods including H -1, C-13, and 2D NMR experiments and mass spectrometry. Compound 3 was the only prenylated stilbene to demonstrate antifungal effects against Cladospo rium cucumerinum. Four of the isolated compounds showed toxic properties ag ainst larvae of the yellow fever-transmitting mosquito Aedes aegypti. Compo und 5 was found to be as potent as rotenone in larvicidal dilution tests.