New prenylated bi- and tricyclic phloroglucinol derivatives from Hypericumpapuanum

Citation
K. Winkelmann et al., New prenylated bi- and tricyclic phloroglucinol derivatives from Hypericumpapuanum, J NAT PROD, 64(6), 2001, pp. 701-706
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
6
Year of publication
2001
Pages
701 - 706
Database
ISI
SICI code
0163-3864(200106)64:6<701:NPBATP>2.0.ZU;2-2
Abstract
Five new prenylated tricyclic and three new bicyclic acylphloroglucinol der ivatives have been isolated by bioactivity-guided fractionation of the petr oleum ether extract of the dried aerial parts of Hypericum papuanum. The tr icyclic compounds (1-5) were named papuaforins A-E. The bicyclic compounds were isolated together with their corresponding tautomers and were named hy perguinones A and B (6/6a, 7/7a) and hyperpapuanone (8/8a), respectively. T heir structures were elucidated on the basis of extensive 1D and 2D NMR exp eriments, as well as mass spectrometry. Furthermore, the cytotoxicity towar d KB nasopharyngeal carcinoma cells and the antibacterial activity of the i solated compounds were determined.