A new dehydrogeranylgeraniol antioxidant from Saururus cernuus that inhibits intracellular reactive oxygen species (ROS)-catalyzed oxidation within HL-60 cells

Citation
I. Rajbhandari et al., A new dehydrogeranylgeraniol antioxidant from Saururus cernuus that inhibits intracellular reactive oxygen species (ROS)-catalyzed oxidation within HL-60 cells, J NAT PROD, 64(6), 2001, pp. 693-695
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
6
Year of publication
2001
Pages
693 - 695
Database
ISI
SICI code
0163-3864(200106)64:6<693:ANDAFS>2.0.ZU;2-X
Abstract
A new triene, 12,13-dehydrogeranylgeraniol (1), was isolated from the aquat ic plant Saururus cernuus and its structure determined spectroscopically. C ompound 1 inhibits PMA-induced peroxide-catalyzed oxidation of 2 ' ,7 ' -di chlorodihydrofluorescein dye (DCFH) by reactive oxygen species (ROS) within human promyelocyctic HL-60 cells.