Bacterial infection promotes colon tumorigenesis in Apc(Min/+) mice

Citation
Jv. Newman et al., Bacterial infection promotes colon tumorigenesis in Apc(Min/+) mice, J INFEC DIS, 184(2), 2001, pp. 227-230
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
JOURNAL OF INFECTIOUS DISEASES
ISSN journal
0022-1899 → ACNP
Volume
184
Issue
2
Year of publication
2001
Pages
227 - 230
Database
ISI
SICI code
0022-1899(20010715)184:2<227:BIPCTI>2.0.ZU;2-H
Abstract
The Min mouse, which has a germ line mutation in 1 allele of the Apc tumor suppressor gene, is a model for the early steps in human colorectal cancer. Helicobacter pylori infection, a known risk factor for gastric cancer in h umans, causes chronic inflammation and increased epithelial cell proliferat ion in the stomach. Infection with the bacterium Citrobacter rodentium is k nown to increase epithelial cell proliferation and to promote chemically in itiated tumors in the colon of mice. Min mice infected with C. rodentium at 1 month of age were found to have a 4-fold increase in the number of colon ic adenomas at 6 months of age, compared with uninfected Min mice. Most of the colonic adenomas in the infected Min mice were in the distal colon, whe re C. rodentium-induced hyperplasia occurs. These data demonstrate that bac terial infection promotes colon tumor formation in genetically susceptible mice.