Concise synthesis of 6-sulfonylated 3,4-dihydro-2H-thiopyrans and 7-sulfonylated 3,4,5,6-tetrahydrothiepines from lactols

Citation
Jk. Gallos et Cc. Dellios, Concise synthesis of 6-sulfonylated 3,4-dihydro-2H-thiopyrans and 7-sulfonylated 3,4,5,6-tetrahydrothiepines from lactols, J HETERO CH, 38(3), 2001, pp. 579-584
Citations number
45
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022-152X → ACNP
Volume
38
Issue
3
Year of publication
2001
Pages
579 - 584
Database
ISI
SICI code
0022-152X(200105/06)38:3<579:CSO63A>2.0.ZU;2-K
Abstract
A concise method for the synthesis of the title compounds has been develope d, which involves condensation of lactols with methylthiomethyl p-tolyl sul fone, followed by mesylation and further cyclisation of the elimination pro ducts by refluxing with excess of sodium iodide in dimethyl formamide (DMF) .