Development of a new drug delivery system for protein drugs using silicone(II)

Citation
M. Kajihara et al., Development of a new drug delivery system for protein drugs using silicone(II), J CONTR REL, 73(2-3), 2001, pp. 279-291
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
JOURNAL OF CONTROLLED RELEASE
ISSN journal
0168-3659 → ACNP
Volume
73
Issue
2-3
Year of publication
2001
Pages
279 - 291
Database
ISI
SICI code
0168-3659(20010615)73:2-3<279:DOANDD>2.0.ZU;2-D
Abstract
In order to achieve a zero-order release of protein drugs, we have develope d a new drug delivery system using silicone, which is named the covered-rod -type formulation. Preparation of the covered-rod-type formulation was cond ucted under mild conditions without heat treatment or the use of organic so lvents. The covered-rod-type formulation released human serum albumin (HSA) or interferon (IFN) at a constant rate for 30-100 days in vitro without si gnificant initial burst. When the IFN covered-rod-type formulation was impl anted in nude mice, the serum IFN concentration was maintained at a constan t level during the period of observation, i.e., 28 days. The covered-rod-ty pe formulation enabled precise control of the release of the protein drugs and would be expected to increase the duration of the drug effect and to re duce the frequency of administration and side effects. (C) 2001 Elsevier Sc ience B.V. All rights reserved.