Expression of p73 and p63 proteins in pancreatic adenocarcinoma: p73 overexpression is inversely correlated with biological aggressiveness

Citation
Y. Ito et al., Expression of p73 and p63 proteins in pancreatic adenocarcinoma: p73 overexpression is inversely correlated with biological aggressiveness, INT J MOL M, 8(1), 2001, pp. 67-71
Citations number
34
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research General Topics
Journal title
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
ISSN journal
1107-3756 → ACNP
Volume
8
Issue
1
Year of publication
2001
Pages
67 - 71
Database
ISI
SICI code
1107-3756(200107)8:1<67:EOPAPP>2.0.ZU;2-D
Abstract
The significance of p53, a prominent tumor suppressor gene, and its product in various neoplasms including pancreatic adenocarcinoma has been establis hed. We investigated the expression of two types of homologue of p53, p73 a nd p63, in pancreatic adenocarcinoma by means of immunohistochemistry. Over expression of p73 was observed in 45.6% of the cases and this phenomenon wa s more frequently seen in cystic adenocarcinomas than in ductal carcinomas. Furthermore, p73 overexpression was inversely linked to lymph node metasta sis, tumor size, and Ki-67 labeling index. On the other hand, p63 overexpre ssion was observed in 68.2% of the cases, but was not related to any clinic opathological features. No correlation was established between the expressi on of these proteins and aberrant p53 expression. These results suggest tha t decreased expression of p73 protein and over-expression of p63 protein ma y play a role in the development of pancreatic adenocarcinoma.