Elevated serum-soluble Fas ligand in histiocytic necrotizing lymphadenitis

Citation
K. Kato et al., Elevated serum-soluble Fas ligand in histiocytic necrotizing lymphadenitis, INT J HEMAT, 73(1), 2001, pp. 84-86
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology
Journal title
INTERNATIONAL JOURNAL OF HEMATOLOGY
ISSN journal
0925-5710 → ACNP
Volume
73
Issue
1
Year of publication
2001
Pages
84 - 86
Database
ISI
SICI code
0925-5710(200101)73:1<84:ESFLIH>2.0.ZU;2-C
Abstract
Recent studies have indicated that Fas and perforin-based mechanisms seem t o induce apoptosis in histiocytic necrotizing lymphadenitis (HNL). In this study, we evaluated the serum levels of soluble Fas ligand (sFasL) in 30 HN L patients using paired sera. Elevations in sFasL levels were detected in 9 patients in the active stage. In the convalescent stage, the levels of sFa sL decreased to an undetectable degree after 2 weeks. These findings indica te thee possibility that sFasL plays an important role in the constitutiona l symptoms and pathogenesis of HNL and, furthermore, that it can act as a s urrogate marker of the disease activity. (C) 2001 The Japanese Society of H ematology.