PDZ-binding kinase participates in spermatogenesis

Citation
Sh. Zhao et al., PDZ-binding kinase participates in spermatogenesis, INT J BIO C, 33(6), 2001, pp. 631-636
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biochemistry & Biophysics
Journal title
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
ISSN journal
1357-2725 → ACNP
Volume
33
Issue
6
Year of publication
2001
Pages
631 - 636
Database
ISI
SICI code
1357-2725(200106)33:6<631:PKPIS>2.0.ZU;2-O
Abstract
A cDNA clone denoted SPK (spermatogenesis-related protein kinase) was isola ted from human fetal brain cDNA library. The deduced protein was 99% identi cal to human PDZ-binding kinase (PBK), which is a mitotic kinase. Its isofo rm, which is about 300 bp longer at 3 ' end, was also isolated in this stud y. SPE: gene was assigned to human chromosome 8p21.2 by radiation hybrid. N orthern blot analysis indicated that SPK mRNA was predominantly expressed i n testis. SPK mRNA was localized to the outer cell layer of seminiferous tu bules by in situ hybridization, suggesting involvement of it in the process of spermatogenesis. (C) 2001 Elsevier Science Ltd. All rights reserved.