A patient with chronic hepatitis C who obtained sustained response by retreatment of interferon after decrease of viral load and mutation in interferon sensitivity determining region

Citation
K. Watanabe et al., A patient with chronic hepatitis C who obtained sustained response by retreatment of interferon after decrease of viral load and mutation in interferon sensitivity determining region, INTERN MED, 40(6), 2001, pp. 489-492
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine
Journal title
INTERNAL MEDICINE
ISSN journal
0918-2918 → ACNP
Volume
40
Issue
6
Year of publication
2001
Pages
489 - 492
Database
ISI
SICI code
0918-2918(200106)40:6<489:APWCHC>2.0.ZU;2-#
Abstract
A 44-year-old man with chronic hepatitis C received three courses of interf eron (IFN) therapy. HCV genotype was Ib, viral load was 1,200 kcopies/ml an d interferon sensitivity determining region (ISDR) was the intermediate typ e before the Ist IFN therapy. The Ist and 2nd IFN therapies resulted in fai lure to yield a sustained response. Seven years after from the Ist therapy, viral load had decreased to 15 kcopies/ml and ISDR had changed to mutant t ype, The 3rd IFN therapy yielded sustained response. Thus, we should consid er retreatment with IFN when a decrease of the viral load and change of ISD R to mutant type are observed.