M. Tabata et al., Peripheral blood stem cell transplantation in patients over 65 years old with malignant lymphoma - Possibility of early completion of chemotherapy and improvement of performance status, INTERN MED, 40(6), 2001, pp. 471-474
Objective After the initial clinical application of peripheral blood stem c
ell transplantation (PBSCT) in the latter half of the 1980s, the frequency
of PBSCT for non-Hodgkin's lymphoma (NHL) has been gradually increasing, At
present, PBSCT is an important procedure for treating young patients with
NHL, This procedure is now being increasingly used as a part of the chemoth
erapy regimen for elderly patients. We evaluated the feasibility of PBSCT i
n elderly patients with malignant lymphoma.
Patients and Methods We performed PBSCT on four older patients over 65 year
s old (median age 71, range 66-78) with aggressive non-Hodgkin's lymphoma.
Patients were initially treated with the THP-COP [cyclophosphamide, THP-dox
orubicin (pirarubicin), vincristine, prednisolone] regimen as first-line ch
emotherapy, As second-line chemotherapy, in partial response (PR) cases, we
performed PBSCT, Conditioning therapy was the MCVC [ranimustine (MCNU), ca
rboplatin, etoposide (VP-16), cyclophosphamide] protocol.
Results PBSC collection and transplantation were possible in all patients.
We observed no severe toxicity. Two of the four patients attained complete
remission (CR). Tumor size was clearly diminished in two PR patients. Perfo
rmance status (PS) was improved in three of the four patients after transpl
Conclusion Despite the small number of cases, this procedure is beneficial
for completing chemotherapy earlier and promoting a good quality of life.