Peripheral blood stem cell transplantation in patients over 65 years old with malignant lymphoma - Possibility of early completion of chemotherapy and improvement of performance status

Citation
M. Tabata et al., Peripheral blood stem cell transplantation in patients over 65 years old with malignant lymphoma - Possibility of early completion of chemotherapy and improvement of performance status, INTERN MED, 40(6), 2001, pp. 471-474
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine
Journal title
INTERNAL MEDICINE
ISSN journal
0918-2918 → ACNP
Volume
40
Issue
6
Year of publication
2001
Pages
471 - 474
Database
ISI
SICI code
0918-2918(200106)40:6<471:PBSCTI>2.0.ZU;2-B
Abstract
Objective After the initial clinical application of peripheral blood stem c ell transplantation (PBSCT) in the latter half of the 1980s, the frequency of PBSCT for non-Hodgkin's lymphoma (NHL) has been gradually increasing, At present, PBSCT is an important procedure for treating young patients with NHL, This procedure is now being increasingly used as a part of the chemoth erapy regimen for elderly patients. We evaluated the feasibility of PBSCT i n elderly patients with malignant lymphoma. Patients and Methods We performed PBSCT on four older patients over 65 year s old (median age 71, range 66-78) with aggressive non-Hodgkin's lymphoma. Patients were initially treated with the THP-COP [cyclophosphamide, THP-dox orubicin (pirarubicin), vincristine, prednisolone] regimen as first-line ch emotherapy, As second-line chemotherapy, in partial response (PR) cases, we performed PBSCT, Conditioning therapy was the MCVC [ranimustine (MCNU), ca rboplatin, etoposide (VP-16), cyclophosphamide] protocol. Results PBSC collection and transplantation were possible in all patients. We observed no severe toxicity. Two of the four patients attained complete remission (CR). Tumor size was clearly diminished in two PR patients. Perfo rmance status (PS) was improved in three of the four patients after transpl antation. Conclusion Despite the small number of cases, this procedure is beneficial for completing chemotherapy earlier and promoting a good quality of life.