A putative GDP-GTP exchange factor is required for development of the excretory cell in Caenorhabditis elegans

Citation
N. Suzuki et al., A putative GDP-GTP exchange factor is required for development of the excretory cell in Caenorhabditis elegans, EMBO REP, 2(6), 2001, pp. 530-535
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Molecular Biology & Genetics
Journal title
EMBO REPORTS
ISSN journal
1469-221X → ACNP
Volume
2
Issue
6
Year of publication
2001
Pages
530 - 535
Database
ISI
SICI code
1469-221X(200106)2:6<530:APGEFI>2.0.ZU;2-B
Abstract
The Caenorhabditis elegans excretory cell extends tubular processes, called canals, along the basolateral surface of the epidermis. Mutations in the e xc-5 gene cause tubulocystic defects in this canal. Ultrastructural analysi s suggests that exc-5 is required for the proper placement of cytoskeletal elements at the apical epithelial surface. exc-5 encodes a protein homologo us to guanine nucleotide exchange factors and contains motif architecture s imilar to that of FGD1, which is responsible for faciogenital dysplasia. ex c-5 interacts genetically with mig-2 which encodes Rho GTPase. These result s suggest that EXC-5 controls the structural organization of the excretory canal by regulating Rho family GTPase activities.