Erythrocytic vacuolar rafts induced by malaria parasites

Citation
K. Haldar et al., Erythrocytic vacuolar rafts induced by malaria parasites, CURR OPIN H, 8(2), 2001, pp. 92-97
Citations number
40
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology
Journal title
CURRENT OPINION IN HEMATOLOGY
ISSN journal
1065-6251 → ACNP
Volume
8
Issue
2
Year of publication
2001
Pages
92 - 97
Database
ISI
SICI code
1065-6251(200103)8:2<92:EVRIBM>2.0.ZU;2-Z
Abstract
Studies in the past year displaced long-standing dogmas and provided many n ew molecular insights into how proteins and solutes move between the erythr ocyte plasma membrane and the malarial vacuole. Highlights include a demons tration that (1) detergent-resistant membrane (DRM) rafts exist in the red cell membrane and their resident proteins are detected as rafts in the plas modial vacuole, (2) a voltage-gated channel in the infected red cell membra ne mediates uptake of extracellular nutrient solutes, and (3) intraerythroc ytic membranes transport a parasite-encoded adherence antigen to the red ce ll surface. (C) 2001 Lippincott Williams & Wilkins, Inc.