Total synthesis of agosterol A: an MDR-modulator from a marine sponge

Citation
N. Murakami et al., Total synthesis of agosterol A: an MDR-modulator from a marine sponge, CHEM-EUR J, 7(12), 2001, pp. 2663-2670
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY-A EUROPEAN JOURNAL
ISSN journal
0947-6539 → ACNP
Volume
7
Issue
12
Year of publication
2001
Pages
2663 - 2670
Database
ISI
SICI code
0947-6539(20010618)7:12<2663:TSOAAA>2.0.ZU;2-4
Abstract
The first total synthesis of agosterol A, a modulator of multidrug resistan ce (MDR) mediated by P-gp and MRP1, and isolated from a marine sponge, was achieved from ergosterol by utilizing a regioselective epoxy-cleavage react ion and regioselective dehydroxylation as the key reactions.