MUC1, glycans and the cell-surface barrier to embryo implantation

Citation
Jd. Aplin et al., MUC1, glycans and the cell-surface barrier to embryo implantation, BIOCH SOC T, 29, 2001, pp. 153-156
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL SOCIETY TRANSACTIONS
ISSN journal
0300-5127 → ACNP
Volume
29
Year of publication
2001
Part
2
Pages
153 - 156
Database
ISI
SICI code
0300-5127(200105)29:<153:MGATCB>2.0.ZU;2-I
Abstract
As it approaches the maternal surface, the attaching embryo encounters the epithelial glycocalyx, which contains the mucin, MUC1. A high density of MU C1 at the cell surface can inhibit cell adhesion. This raises the possibili ty of the existence of a uterine barrier to implantation that might allow m aternal rejection of poorer quality embryos. To investigate the mechanism o f implantation, human embryos were incubated with endometrial epithelial mo nolayers. Hatched blastocysts were found to attach readily to the epithelia l surface. MUC1 was lost from epithelial cells beneath and near to the atta ched embryo, while normal expression persisted in neighbouring cells.