New local hyperthermia using dextran magnetite complex (DM) for oral cavity: experimental study in normal hamster tongue

Citation
S. Wada et al., New local hyperthermia using dextran magnetite complex (DM) for oral cavity: experimental study in normal hamster tongue, ORAL DIS, 7(3), 2001, pp. 192-195
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Dentistry/Oral Surgery & Medicine
Journal title
ORAL DISEASES
ISSN journal
1354-523X → ACNP
Volume
7
Issue
3
Year of publication
2001
Pages
192 - 195
Database
ISI
SICI code
1354-523X(200105)7:3<192:NLHUDM>2.0.ZU;2-C
Abstract
The possibility of dextran magnetite complex (DM) as a new hyperthermic mat erial was examined in this study. DM suspension of 56 mg ml(-1) iron concen tration was locally injected into the normal tongue of golden hamster. DM i njected tongues were heated by 500 kHz alternating current (AC) magnetic fi eld and its serial changes in temperature were recorded at 30-s intervals, The temperature of DM injected tongue was maintained at about 43.0-45.0 deg reesC for 30 min by changing the AC magnetic field intensity. While tempera ture elevations of the contralateral tongue and the rectum were only of min or degree, In experiment on the extent of heating area, there was correlati on between volume of black stain area and amount of the injected DM suspens ion (Y = -18.1 + 1.94X, r = 0,931, P < 0.0001, n = 9), Histological examina tion after heating revealed brown uniform DM accumulation in the connective tissue between fibers of the tongue muscle. Except for vascular dilatation s, no tissue damage was seen in the heated tongue. Thus, DM which has the p ossibility of selective and uniform heating in local hyperthermia might be useful for oral cancer therapy.