Does loperamide affect motor activity after proctocolectomy and ileal pouch-anal anastomosis? An experimental study in dogs

Citation
S. Willis et al., Does loperamide affect motor activity after proctocolectomy and ileal pouch-anal anastomosis? An experimental study in dogs, INT J COL R, 16(3), 2001, pp. 182-187
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
ISSN journal
0179-1958 → ACNP
Volume
16
Issue
3
Year of publication
2001
Pages
182 - 187
Database
ISI
SICI code
0179-1958(200106)16:3<182:DLAMAA>2.0.ZU;2-Z
Abstract
This study investigated the effect of loperamide on the motor function of s mall intestine and J-pouch. Proctocolectomy and ileal pouch-anal anastomosi s were performed in four dogs. Motility was recorded by serosal electrodes and strain gauge transducers. The intestinal transit time was determined ra diologically. Multiple measurements were performed before and during chroni c administration of loperamide. This treatment led to a significant decreas e in median stool frequency from 11 (10-13) to 9 stools/day (8-12) and a te ndential increase in intestinal transit time from 60 (50-105) to 70 min (60 -90). This was not accompanied by significant changes in fasted or postpran dial motility. There were no significant differences in the characteristics of the migrating myoelectric complex or in the fed pattern, either in the small intestine or in the pouch. Loperamide thus does not significantly aff ect intestinal motility after ileal pouch-anal anastomosis. The reduction i n stool frequency seems to be due to antisecretory effects in the first lin e.