"Hepatitic flare", asthenia, peripheral polyneuropathy and diffuse liver steatosis in a hepatitis C virus asymptomatic chronic carrier

Citation
F. Caprioli et al., "Hepatitic flare", asthenia, peripheral polyneuropathy and diffuse liver steatosis in a hepatitis C virus asymptomatic chronic carrier, DIG LIVER D, 33(4), 2001, pp. 359-362
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
DIGESTIVE AND LIVER DISEASE
ISSN journal
1590-8658 → ACNP
Volume
33
Issue
4
Year of publication
2001
Pages
359 - 362
Database
ISI
SICI code
1590-8658(200105)33:4<359:"FAPPA>2.0.ZU;2-B
Abstract
In July 2000, a 62-year-old female, with a ten-year history of chronic hepa titis C virus infection and persistently normal aspartate aminotransferase and alanine aminotransferase levels, presented with asthenia, weight loss, peripheral polyneuropathy and increased levels of aspartate aminotransferas e (8 times upper normal limit), alanine aminotransferase (10 times upper no rmal limit) and gamma glutamyltransferase (6 times upper normal limit). The ultrasound findings were consistent with massive liver steatosis. The pati ent had been previously diagnosed elsewhere as having hepatitis C virus-rel ated "hepatitic flare" with neurological involvement related to concomitant mixed type-ill cryoglobulinaemia. However: intense exposure to trichloroet hylene since April 2000 was revealed and liver histology was fully consiste nt with non-alcoholic steatohepatitis. The pathogenetic role of the solvent was definitely supported by the complete clinical and biochemical remissio n within six months of trichloroethylene withdrawal.