Calcitonin-like substance in the plasma of Cyclostomata and its putative role

Authors
Citation
N. Suzuki, Calcitonin-like substance in the plasma of Cyclostomata and its putative role, COMP BIOC B, 129(2-3), 2001, pp. 319-326
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biochemistry & Biophysics
Journal title
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
ISSN journal
1096-4959 → ACNP
Volume
129
Issue
2-3
Year of publication
2001
Pages
319 - 326
Database
ISI
SICI code
1096-4959(200106)129:2-3<319:CSITPO>2.0.ZU;2-V
Abstract
The present study indicated that in the lamprey, Lampetra japonica, which u ndersoes a spawning migration from seawater to freshwater in its life cycle , a calcitonin (CT)-like substance was not detected in the plasma of seawat er-adapted specimens (both sexes), but it was detected in the plasma of fre shwater-adapted specimens (both sexes) by enzyme-linked immunosorbent assay using anti-salmon CT serum. Furthermore, this substance increased with the gonad somatic index (GSI) in both sexes. In lamprey, therefore, this CT-li ke substance may have some relationship with gonadal maturation. In the pla sma of the hagfish, Eptatretus burgeri, on the other hand, the CT-like subs tance was always extremely high (47.2 +/- 4.2 ng/ml) independently of GSI i n both sexes. However, a correlation was found between this substance and p lasma calcium. In hagfish, the CT-like substance may participate in calcium homeostasis, as does calcium excretion via bile, because the hagfish has t he highest bile calcium concentration determined to date among vertebrates, with a level corresponding to 12-fold that in plasma. This speculation is supported by reports that, in rat and cartilaginous fish, CT acts on calciu m excretion via bile. In both fishes, moreover, the molecular weight of the se substances was equal to that of salmon CT, which strongly suggests that these substances detected here are their CTs. (C) 2001 Elsevier Science Inc . All rights reserved.