Protection against cold air and exercise-induced bronchoconstriction whileon regular treatment with Oxis((R))

Citation
J. Vilsvik et al., Protection against cold air and exercise-induced bronchoconstriction whileon regular treatment with Oxis((R)), RESP MED, 95(6), 2001, pp. 484-490
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems","da verificare
Journal title
RESPIRATORY MEDICINE
ISSN journal
0954-6111 → ACNP
Volume
95
Issue
6
Year of publication
2001
Pages
484 - 490
Database
ISI
SICI code
0954-6111(200106)95:6<484:PACAAE>2.0.ZU;2-F
Abstract
This study aimed to compare the duration of protection against exercise-ind uced bronchoconstriction. (EIB) after inhalation of formoterol (Oxis (R)) T urbuhaler (R) with that of terbutaline Turbuhaler (R) and placebo Turbuhale r (R) in asthmatic patients treated regularly with formoterol Turbuhaler (R ) 9 mug b.i.d. and inhaled steroids. The study, performed at three centres (Goteborg and Lund, Sweden, and Trond heim, Norway), consisted of an open-label part with formoterol Turbuhaler ( R) 9 mug b.i.d. and a randomized, double-blind, cross-over part with a sing le dose (on top of the regular treatment) of either formoterol Turbuhaler ( R) 9 mug, terbutaline Turbuhaler (R) 0.5mg or placebo Turbuhaler (R). The p atients attended the clinic six times: twice for screening visits, three ti mes for randomized treatment and once for a follow-up visit. Patients recei ved regular b.i.d, treatment with formoterol 9 mug for a mean period of 16 days. Formoterol gave a post-exercise fall of 12, 10, 15 and 17% in forced expira tory volume in 1 sec (FEV1) 15 min, 4, 8 and 12h after inhalation. The diff erences compared with placebo (falls of 26, 22, 23 and 22%) and terbutaline (falls of 17, 18, 22 and 22%) were all statistically significant (P <0.05 for all comparisons). Patients on regular treatment with formoterol Turbuhaler (R) 9 mug b.i.d. h ave a significant protection against EIB up to 12h after inhalation of form oterol 9 mug. The protection was also significantly batter than that of ter butaline Turbuhaler (R) 0.5 mg.