Effects of rat medial prefrontal cortex temporal inactivation on a delayedalternation task

Citation
Y. Izaki et al., Effects of rat medial prefrontal cortex temporal inactivation on a delayedalternation task, NEUROSCI L, 315(3), 2001, pp. 129-132
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
0304-3940 → ACNP
Volume
315
Issue
3
Year of publication
2001
Pages
129 - 132
Database
ISI
SICI code
0304-3940(20011127)315:3<129:EORMPC>2.0.ZU;2-S
Abstract
To determine the involvement of the medial prefrontal cortex (mPFC) in oper ant-type delayed alternation, microinjections of muscimol into the mPFC wer e used for temporal inactivation during behavioral tests in rats. The tempo ral mPFC inactivation showed effects related to both dorsal (decreased dela y-dependent correct ratio, indicating working memory-related deficits) and ventral hippocampus inactivation (increased tendency to repeat errors) repo rted in our recent paper, without motor or sensory effects. These findings suggest that the mPFC integrates information from different hippocampal reg ions during a delayed alternation task. (C) 2001 Elsevier Science Ireland L td. All rights reserved.