GABA(B) receptor activation enhances mGIuR-mediated responses at cerebellar excitatory synapses

Citation
M. Hirono et al., GABA(B) receptor activation enhances mGIuR-mediated responses at cerebellar excitatory synapses, NAT NEUROSC, 4(12), 2001, pp. 1207-1216
Citations number
50
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NATURE NEUROSCIENCE
ISSN journal
1097-6256 → ACNP
Volume
4
Issue
12
Year of publication
2001
Pages
1207 - 1216
Database
ISI
SICI code
1097-6256(200112)4:12<1207:GRAEMR>2.0.ZU;2-2
Abstract
Metabotropic gamma -aminobutyric acid type B (GABA(B)) and glutamate recept ors (mGluRs) are postsynaptically co-expressed at cerebellar parallel fiber (PF)-Purkinje cell (PC) excitatory synapses, but their functional interact ions are unclear. We found that mGluR1 agonist-induced currents and [Ca2+]( i) increases in PCs were enhanced following co-activation of GABA(B) recept ors. A GABA(B) antagonist and a G-protein uncoupler suppressed these effect s. Low-concentration baclofen, a GABA(B) agonist, augmented mGluR1-mediated excitatory synaptic current produced by stimulating PFs. These results ind icate that postsynaptic GABA(B) receptors functionally interact with mGluR1 and enhance mGluR1-mediated excitatory transmission at PF-PC synapses. The interaction between the two types of metabotropic receptors provides a lik ely mechanism for regulating cerebellar synaptic plasticity.