Role of id family proteins in growth control

Authors
Citation
Y. Yokota et S. Mori, Role of id family proteins in growth control, J CELL PHYS, 190(1), 2002, pp. 21-28
Citations number
121
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
JOURNAL OF CELLULAR PHYSIOLOGY
ISSN journal
0021-9541 → ACNP
Volume
190
Issue
1
Year of publication
2002
Pages
21 - 28
Database
ISI
SICI code
0021-9541(200201)190:1<21:ROIFPI>2.0.ZU;2-X
Abstract
Id proteins (inhibitors of DNA binding/differentiation) are negative regula tors of basic helix-loop-helix (bHLH) type transcription factors, which pro mote the differentiation of various cell types. In addition to their "class ical" ability to inhibit cell differentiation, they are able to stimulate c ell cycle progression. These facts suggest that Id proteins play a role in keeping precursor cells immature and in expanding the cell population size during development. In vitro as well as in vivo analyses in the last severa l years have shown that Id proteins have more complex activities; they indu ce apoptosis or function as survival factors, depending on the cell context . Furthermore, dysregulated expression of Id proteins has been reported in several human tumors and seems to be related to the malignant character of tumors. Here, we summarize and discuss the biological activities of Id prot eins from the standpoint of cell growth control. (C) 2002 Wiley-Liss, Inc.