PATHOGENETIC IMPLICATION OF INTERLEUKIN-2 EXPRESSED IN PREECLAMPTIC DECIDUAL TISSUES - A POSSIBLE MECHANISM OF DERANGED VASCULATURE OF THE PLACENTA ASSOCIATED WITH PREECLAMPSIA

Citation
Y. Hamai et al., PATHOGENETIC IMPLICATION OF INTERLEUKIN-2 EXPRESSED IN PREECLAMPTIC DECIDUAL TISSUES - A POSSIBLE MECHANISM OF DERANGED VASCULATURE OF THE PLACENTA ASSOCIATED WITH PREECLAMPSIA, American journal of reproductive immunology [1989], 38(2), 1997, pp. 83-88
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Reproductive Biology",Immunology
ISSN journal
1046-7408
Volume
38
Issue
2
Year of publication
1997
Pages
83 - 88
Database
ISI
SICI code
1046-7408(1997)38:2<83:PIOIEI>2.0.ZU;2-E
Abstract
PROBLEM: The purpose of this study is to clarify whether IL-2 expresse d in the decidua in preeclampsia affects the angiogenesis of the place nta. METHOD OF STUDY: We investigated the angiogenic substances releas ed from human trophoblasts obtained from early pregnancy that had been pretreated with either IL-2, nonactivated lymphocytes from peripheral blood mononuclear cells (PBMCs), decidual lymphocytes, or these lymph ocytes activated by lymphokine (LAK cells). Angiogenic activity was de termined by evaluating the ability of growth-promotion of cultured hum an microvascular endothelial cells (HMvECs) using MTT assay. RESULTS: Trophoblasts pretreated with IL-2 or non-activated lymphocytes, irresp ective of their origin, released angiogenic factor similar to those wi thout pretreatment. However, trophoblasts pretreated with LAK tells re leased less angiogenic factor compared with those without pretreatment . CONCLUSIONS: Interleukin-2 (IL-2) expressed in preeclamptic decidua might reduce the angiogenic substances arising from trophoblasts by in ducing LAK cells from decidual lymphocytes, which might be relevant to deranged vasculature of the placenta, a characteristic histology in p reeclampsia.