Neurometabolic changes during treatment with moderate hypothermia in a patient suffering from severe middle cerebral artery infarction

Citation
Wr. Schabitz et al., Neurometabolic changes during treatment with moderate hypothermia in a patient suffering from severe middle cerebral artery infarction, CEREB DIS, 12(4), 2001, pp. 298-302
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
CEREBROVASCULAR DISEASES
ISSN journal
1015-9770 → ACNP
Volume
12
Issue
4
Year of publication
2001
Pages
298 - 302
Database
ISI
SICI code
1015-9770(2001)12:4<298:NCDTWM>2.0.ZU;2-I
Abstract
Microdialysis is a means of measuring neurochemical changes in the extracel lular space and has been applied in acute brain trauma, subarachnoid hemorr hage and stroke patients. In this study, we monitored neurochemical changes in the extracellular space using microdialysis in a patient with left-side d hemispheric infarction treated with moderate hypothermia (33 degreesC). M icrodialysis probes were obtained from the infarcted and noninfarcted hemis phere during hypothermia and rewarming. Concentrations of extracellular sub stances in the infarcted hemisphere (glutamate, glycerine, lactate/pyruvate ) decreased with hypothermia and remained stable (glutamate) or increased ( glycerine, lactate/pyruvate) during rewarming. Concentrations of these subs tances in the noninfarcted hemisphere remained at normal levels. Microdialy sis monitoring of therapeutic hypothermia in severe hemispheric infarction might be a useful additional monitoring tool to assess the status of the br ain and to predict further deterioration. Copyright (C) 2001 S. Karger AG, Basel.