Plasma concentration of tissue inhibitor of matrix metalloproteinase 1 in patients with colorectal carcinoma

Citation
N. Yukawa et al., Plasma concentration of tissue inhibitor of matrix metalloproteinase 1 in patients with colorectal carcinoma, BR J SURG, 88(12), 2001, pp. 1596-1601
Citations number
31
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Surgery,"Medical Research Diagnosis & Treatment
Journal title
BRITISH JOURNAL OF SURGERY
ISSN journal
0007-1323 → ACNP
Volume
88
Issue
12
Year of publication
2001
Pages
1596 - 1601
Database
ISI
SICI code
0007-1323(200112)88:12<1596:PCOTIO>2.0.ZU;2-6
Abstract
Background: The expression of tissue inhibitor of matrix metalloproteinase (TIMP) 1 in tumour tissue from patients with colorectal carcinoma has been reported to be related to disease progression. However, the clinical signif icance of plasma TIMP-1 has not been fully, elucidated. Methods: The plasma level of TIMP-1 protein was determined by enzyme-linked immunosorbent assay in samples from 54 patients who underwent resection of the primary tumour. Results: Plasma TIMP-1 levels were associated significantly, with depth of invasion and metastasis to lymph nodes and liver. Circulating TIMP-1 levels were significantly, higher in patients with serosal invasion, liver metast ases and Dukes' stage C tumours. Using a cut-off value of 160 ng/ml, serosa l invasion and Dukes' C stage could be predicted with an accuracy of 68.5 p er cent. With a cut-off value of 170 ng/ml, metastasis to the lymph node an d liver could be predicted with an accuracy of 66.7 and 70.4 per cent respe ctively. These values were greater than those for carcinoembryonic antigen and CA19-9. Conclusion: These data suggest that the plasma concentration of TIMP-1 corr elates with both invasion and metastasis in patients with colorectal carcin oma.