The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease

Citation
G. Aliev et al., The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease, BRAIN PATH, 12(1), 2002, pp. 21-35
Citations number
142
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN PATHOLOGY
ISSN journal
1015-6305 → ACNP
Volume
12
Issue
1
Year of publication
2002
Pages
21 - 35
Database
ISI
SICI code
1015-6305(200201)12:1<21:TROOSI>2.0.ZU;2-4
Abstract
Alzheimer's disease (AD) and stroke are two leading causes of age-associate d dementia. A rapidly growing body of evidence Indicates that increased oxi dative stress from reactive oxygen radicals is associated with the aging pr ocess and age-related degenerative disorders such as atherosclerosis, Ische mia/reperfusion, arthritis, stroke, and neurodegenerative diseases. New evi dence has also indicated that vascular lesions are a key factor in the deve lopment of AD. This Idea is based on a positive correlation between AD and cardiovascular and cerebrovascular diseases such as arterio- and atheroscle rosis and ischemia/reperfusion injury. In this review we consider recent ev idence supporting the existence of an intimate relationship between oxidati ve stress and vascular lesions in the pathobiology of AD. We also consider the opportunities for therapeutic interventions based on the molecular path ways involved with these causal relationships.