Conditioning with high-dose cyclophosphamide may not be sufficient to provide a long-term remission of paroxysmal nocturnal hemoglobinuria following syngeneic peripheral blood stem cell transplantation

Citation
Sg. Cho et al., Conditioning with high-dose cyclophosphamide may not be sufficient to provide a long-term remission of paroxysmal nocturnal hemoglobinuria following syngeneic peripheral blood stem cell transplantation, BONE MAR TR, 28(10), 2001, pp. 987-988
Citations number
10
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Medical Research Diagnosis & Treatment
Journal title
BONE MARROW TRANSPLANTATION
ISSN journal
0268-3369 → ACNP
Volume
28
Issue
10
Year of publication
2001
Pages
987 - 988
Database
ISI
SICI code
0268-3369(200111)28:10<987:CWHCMN>2.0.ZU;2-U
Abstract
A patient with paroxysmal nocturnal hemoglobinuria (PNH) received a syngene ic peripheral blood stem cell transplant (PBSCT) with high-dose cyclophosph amide (CY) conditioning. He had a reasonable engraftment and complete hemat ologic recovery. However, at 12 months after PBSCT, he became symptomatic a nd peripheral blood cells were almost entirely composed of glycosylphosphat idylinositol-anchored proteins deficient cells. This case suggests that hig h-dose CY may not exert a significant effect on PNH clones in the long term , although it had been effective in allogeneic BMT. In view of the possible autoimmune basis, it seems to be necessary to include other immunosuppress ive therapy including ALG in addition to CY.