Conditioning with high-dose cyclophosphamide may not be sufficient to provide a long-term remission of paroxysmal nocturnal hemoglobinuria following syngeneic peripheral blood stem cell transplantation
Sg. Cho et al., Conditioning with high-dose cyclophosphamide may not be sufficient to provide a long-term remission of paroxysmal nocturnal hemoglobinuria following syngeneic peripheral blood stem cell transplantation, BONE MAR TR, 28(10), 2001, pp. 987-988
Citations number
10
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Medical Research Diagnosis & Treatment
A patient with paroxysmal nocturnal hemoglobinuria (PNH) received a syngene
ic peripheral blood stem cell transplant (PBSCT) with high-dose cyclophosph
amide (CY) conditioning. He had a reasonable engraftment and complete hemat
ologic recovery. However, at 12 months after PBSCT, he became symptomatic a
nd peripheral blood cells were almost entirely composed of glycosylphosphat
idylinositol-anchored proteins deficient cells. This case suggests that hig
h-dose CY may not exert a significant effect on PNH clones in the long term
, although it had been effective in allogeneic BMT. In view of the possible
autoimmune basis, it seems to be necessary to include other immunosuppress
ive therapy including ALG in addition to CY.