Salvage therapy for multiple myeloma with thalidomide and CED chemotherapy

Citation
Tm. Moehler et al., Salvage therapy for multiple myeloma with thalidomide and CED chemotherapy, BLOOD, 98(13), 2001, pp. 3846-3848
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
BLOOD
ISSN journal
0006-4971 → ACNP
Volume
98
Issue
13
Year of publication
2001
Pages
3846 - 3848
Database
ISI
SICI code
0006-4971(200112)98:13<3846:STFMMW>2.0.ZU;2-3
Abstract
The feasibility and efficacy of a combination of thalidomide, cyclophospham ide, etoposide, and dexamethasone were studied in 56 patients with poor-pro gnosis multiple myeloma. Of 50 patients evaluable for response, 4% achieved complete response (CR), 64% partial response (PR), 18% minimal response (M R), 6% stable disease (SD), and 8% progressive disease (PD), resulting in a n objective response rate ( : MR) of 86.0% (76.7% over-all objective respon se rate in intent-to-treat analysis; n = 56). Subsequent to successful remi ssion induction, 18 patients received autologous or allogeneic stem cell tr ansplantation. The median progression-free survival in all patients was 16 months. The median overall survival time could not be calculated, since the last observed death occurred after 16 months of follow-up (median follow-u p of 14 months) with a corresponding estimated survival probability of 55%. Severe adverse effects (World Health Organization III/IV) included Infecti ous complications (35.7%) and cardiovascular events (7.1%). The data sugges t that Thai improves antitumor activity of salvage chemotherapy regimens in poor-prognosis multiple myeloma. (C) 2001 by The American Society of Hemat ology.