Thermodynamic yield predictions for biodegradation through oxygenase activation reactions

Authors
Citation
Jm. Vanbriesen, Thermodynamic yield predictions for biodegradation through oxygenase activation reactions, BIODEGRADAT, 12(4), 2001, pp. 265-281
Citations number
74
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biotecnology & Applied Microbiology
Journal title
BIODEGRADATION
ISSN journal
0923-9820 → ACNP
Volume
12
Issue
4
Year of publication
2001
Pages
265 - 281
Database
ISI
SICI code
0923-9820(2001)12:4<265:TYPFBT>2.0.ZU;2-I
Abstract
Activation reactions involve modification of recalcitrant substrates to for ms that are more readily degradable. These reactions require specialized en zymes and cosubstrates, including molecular oxygen and reduced electron car riers. In these reactions, microorganisms invest electrons and cannot captu re energy or carbon for synthesis. The subsequent degradation of the interm ediates formed in activation reactions releases electrons, energy, and carb on that the organisms use for growth. The overall yield is reduced due to t he required activation investments. A mathematical method to predict cell y ields of oxygenase activation reactions is developed using electron and ene rgy balances. Predicted yields are compared with experimental yields for me thane, organic chelating agents, and aromatic hydrocarbons.