A man with hereditary exostoses and high-grade non-Hodgkin's lymphoma of the bone

Citation
K. Neben et al., A man with hereditary exostoses and high-grade non-Hodgkin's lymphoma of the bone, ANN HEMATOL, 80(11), 2001, pp. 682-684
Citations number
9
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
ANNALS OF HEMATOLOGY
ISSN journal
0939-5555 → ACNP
Volume
80
Issue
11
Year of publication
2001
Pages
682 - 684
Database
ISI
SICI code
0939-5555(200111)80:11<682:AMWHEA>2.0.ZU;2-#
Abstract
Multiple cartilaginous exostoses (NICE) is an autosomal dominant disorder t hat can lead to malignant transformation from exostoses to a secondary chon drosarcoma. We present a case report of a 52-year-old man with NICE who had a palpable mass at the left shoulder. At the site of the left proximal hum erus, a cartilaginous exostosis was localized, suggesting that the tumor de veloped by a malignant trans format ion of an exostosis into a secondary ch ondrosarcoma. Interestingly, a biopsy showed a diffuse large B-cell lymphom a with Burkitt-like features. To our knowledge, the association of high-gra de lymphoma and hereditary exostoses has not been described previously. Thi s case demonstrates that a malignant tumor at the location of a cartilagino us exostosis is not necessarily a chondrosarcoma and that a biopsy is an es sential part of the diagnostic work-up.