Unfolding rates for the diffusion-collision model - art. no. 052902

Citation
C. Beck et X. Siemens, Unfolding rates for the diffusion-collision model - art. no. 052902, PHYS REV E, 6405(5), 2001, pp. 2902
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Physics
Journal title
PHYSICAL REVIEW E
ISSN journal
1063-651X → ACNP
Volume
6405
Issue
5
Year of publication
2001
Part
1
Database
ISI
SICI code
1063-651X(200111)6405:5<2902:URFTDM>2.0.ZU;2-V
Abstract
In the diffusion-collision model, the unfolding rates are given by the like lihood of secondary structural cluster dissociation. In this work, we intro duce an unfolding rate calculation for proteins whose secondary structural elements are alpha helices, modeled from thermal escape over a barrier that arises from the free energy in buried hydrophobic residues. Our results ar e in good agreement with currently accepted values for the attempt rate.