Adenosine A(2A), 5-HT1A, and 5-HT7 receptor in neonatally pregnenolone-treated rats

Authors
Shirayama, Y Muneoka, KT Takigawa, M Minabe, Y
Citation
Y. Shirayama et al., Adenosine A(2A), 5-HT1A, and 5-HT7 receptor in neonatally pregnenolone-treated rats, NEUROREPORT, 12(17), 2001, pp. 3773-3776
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
0959-4965 → ACNP
Volume
12
Issue
17
Year of publication
2001
Pages
3773 - 3776
Database
ISI
SICI code
0959-4965(200112)12:17<3773:AA5A5R>2.0.ZU;2-G
Abstract
Steroid hormones synthesized in the brain, called 'neurosteroids', modulate neuronal activity. We treated, neonatal rats with a main precursor of the neurosteroidogenesis, pregnenolone, and examined adenosine A(2A) receptor, 5-hydroxytryptamine (5-HT)(1A) and 5-HT7 receptor densities in the front-pa rietal cortex in juvenile and adult rats. In receptor binding assay using [ H-3]CGS21680 and [H-3]8-OH-DPAT, it was shown that neonatal pregnenolone-tr eatment induced a significant decrease in the adenosine A2A receptor densit y with no significant effects on the 5-HT1A and 5-HT7 receptor densities. N euroReport 12:3773-3776 (C) 2001 Lippincott Williams & Wilkins.