IL-10 improves skin disease and modulates endothelial activation and leukocyte effector function in patients with psoriatic arthritis

Citation
Ib. Mcinnes et al., IL-10 improves skin disease and modulates endothelial activation and leukocyte effector function in patients with psoriatic arthritis, J IMMUNOL, 167(7), 2001, pp. 4075-4082
Citations number
52
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
JOURNAL OF IMMUNOLOGY
ISSN journal
0022-1767 → ACNP
Volume
167
Issue
7
Year of publication
2001
Pages
4075 - 4082
Database
ISI
SICI code
0022-1767(20011001)167:7<4075:IISDAM>2.0.ZU;2-1
Abstract
Psoriatic arthritis (PsA) provides an ideal disease model in which to inves tigate the bioactivities of potentially therapeutic cytokines at multiple s ites of tissue inflammation. We investigated the effects of IL-10, an antii nflammatory cytokine, given s.c. for 28 days in a double-blind, placebo-con trolled study in PsA patients. Synovial/skin biopsies, peripheral blood leu kocytes, articular magnetic resonance images, and clinical disease activity scores were obtained sequentially. Modest, but significant clinical improv ement in skin, but not articular disease activity scores with only minor ad verse effects was observed. Type 1, but not type 2 T cell cytokine producti on in vitro was suppressed in human rIL-10 compared with placebo recipients . Similarly, monokine production in vitro was reduced, whereas serum solubl e TNFRII levels were elevated, indicating suppression of monocyte function. Decreased T cell and macrophage infiltration in synovial tissues was accom panied by reduced P-selectin expression. Moreover, suppressed synovial enha ncement on magnetic resonance imaging and reduced alpha (v)beta (3) integri n expression on von Willebrand factor(+) vessels were observed. Together th ese data demonstrate that a short course of IL-10 modulates immune response s in vivo via diverse effects on endothelial activation, and leukocyte recr uitment and effector function. Such biological changes may result in clinic ally meaningful improvement in disease activity.