Local costimulation reinvigorates tumor-specific cytolytic T lymphocytes for experimental therapy in mice with large tumor burdens

Citation
Xf. Bai et al., Local costimulation reinvigorates tumor-specific cytolytic T lymphocytes for experimental therapy in mice with large tumor burdens, J IMMUNOL, 167(7), 2001, pp. 3936-3943
Citations number
37
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
JOURNAL OF IMMUNOLOGY
ISSN journal
0022-1767 → ACNP
Volume
167
Issue
7
Year of publication
2001
Pages
3936 - 3943
Database
ISI
SICI code
0022-1767(20011001)167:7<3936:LCRTCT>2.0.ZU;2-P
Abstract
Cytotoxic T cells recognize tumor Ags and destroy cancer cells in vitro. Ad optive transfer studies with transgenic T cells specific for tumor Ags have demonstrated that CTL are effective only in mice with small tumor burdens and thus appear to have limited potential in cancer immunotherapy. Here we used transgenic mice that express the TCR specific for an unmutated tumor A g P1A and multiple lineages of P1A-expressing tumors to address this critic al issue. We found that local costimulation, either by expression of B7-1 o n the tumor cells or by local administration of anti-CD28 mAb 37N, reinvigo rated the function of CTL specific for the tumor Ag, as it substantially in creased the efficacy of CTL therapy for mice with large tumor burdens. Our study suggests that CTL-based immunotherapy can be manipulated to deal with large tumors.