The channel of death

Citation
A. Degterev et al., The channel of death, J CELL BIOL, 155(5), 2001, pp. 695-697
Citations number
19
Language
INGLESE
art.tipo
Editorial Material
Categorie Soggetti
Cell & Developmental Biology
Journal title
JOURNAL OF CELL BIOLOGY
ISSN journal
0021-9525 → ACNP
Volume
155
Issue
5
Year of publication
2001
Pages
695 - 697
Database
ISI
SICI code
0021-9525(20011126)155:5<695:TCOD>2.0.ZU;2-Q
Abstract
The proapoptotic members of the Bcl-2 family have been proposed to particip ate in the formation of a channel that releases these apoptogenic factors w hen mitochondria receive apoptotic signals. A recent study provides the fir st direct, biophysical measurement of a potentially apoptosis-specific mito chondrial channel, which is regulated by Bcl-2 family members and may play a primary role in the release of the proapoptotic factors.