Calorie restriction reduced blood pressure in obesity hypertensives by improvement of autonomic nerve activity and insulin sensitivity

Citation
Y. Nakano et al., Calorie restriction reduced blood pressure in obesity hypertensives by improvement of autonomic nerve activity and insulin sensitivity, J CARDIO PH, 38, 2001, pp. S69-S74
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
ISSN journal
0160-2446 → ACNP
Volume
38
Year of publication
2001
Supplement
1
Pages
S69 - S74
Database
ISI
SICI code
0160-2446(200110)38:<S69:CRRBPI>2.0.ZU;2-J
Abstract
Association between obesity and hypertension has been well recognized. A re duction in the body weight of overweight hypertensive patients is a recomme nded lifestyle modification. The purpose of our study is to examine the rel ationship of insulin sensitivity and autonomic nervous activity with reduct ion of blood pressure by the calorie restriction. We evaluated the heart ra te variability, nocturnal change of blood pressure and insulin resistance b efore and after a short-term low-calorie diet in 12 overweight essential hy pertensives. After a week of standard diet (2000 kcal), 2 weeks of low-calo rie diet (800 kcal) with normal sodium content induced a significant reduct ion in body mass index, triglyceride, fasting immunoreactive protein, homeo stasis model assessment as an index of insulin resistance, and urinary excr etion of sodium and potassium. Systolic blood pressure was significantly re duced both in daytime and night-time after the low-calorie diet (daytime, 1 34.5 +/- 6.0 to 122.0 +/- 4.1 mmHg; night-time, 126.8 +/- 5.2 to 113.4 +/- 7.2 mmHg). In daytime, diastolic blood pressure was also reduced (90.3 +/- 2.1 to 88.1 +/- 4.8 mmHg). Although heart rate was not significantly reduce d, a rise of high frequency in night-time (346 +/- 82 to 572 +/- 108 ms(2)) and a fall of low frequency/high frequency in daytime (3.5 +/- 0.4 to 2.6 +/- 0.1) was significant after a low-calorie diet. In conclusion, weight lo ss by low-calorie diet with a constant intake of sodium, reduced blood pres sure in obese hypertensives by improvement of vagal nervous activity and in sulin resistance.