Genome and hormones: Gender differences in physiology selected contribution: Effects of gender on reduced-size liver ischemia and reperfusion injury

Citation
H. Harada et al., Genome and hormones: Gender differences in physiology selected contribution: Effects of gender on reduced-size liver ischemia and reperfusion injury, J APP PHYSL, 91(6), 2001, pp. 2816-2822
Citations number
48
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Physiology
Journal title
JOURNAL OF APPLIED PHYSIOLOGY
ISSN journal
8750-7587 → ACNP
Volume
91
Issue
6
Year of publication
2001
Pages
2816 - 2822
Database
ISI
SICI code
8750-7587(200112)91:6<2816:GAHGDI>2.0.ZU;2-J
Abstract
Hepatic resection with concomitant periods of ischemia and reperfusion (I/R ) is a common occurrence in resectional surgery as well as reduced-size liv er transplantation (e.g., split liver or living donor transplantation). How ever, the I/R induced by these types of surgical manipulations may impair l iver regeneration, ultimately leading to liver failure. The objectives of t he study were to develop a murine model of reduced-size liver I/R and asses s the role of gender in this model of hepatocellular injury. We found that 100% of female mice survived the surgery indefinitely, whereas all male mic e had greater initial liver injury and died within 5 days after surgery. Th e protective effect observed in females appeared to be due to ovarian 17 be ta -estradiol, as ovariectomy of females or administration of a selective e strogen antagonist to female mice resulted in enhanced liver injury and gre ater mortality following reduced-size liver I/R, Conversely, 17 beta -estra diol-treated male mice exhibited less hepatocellular damage and survived in definitely. Taken together, these data demonstrate an estrogen-mediated pro tective pathway(s) that limits or attenuates hepatocellular injury induced by reduced-size liver I/R.