CJ-15,183, a new inhibitor of squalene synthase produced by a fungus, Aspergillus aculeatus

Citation
S. Watanabe et al., CJ-15,183, a new inhibitor of squalene synthase produced by a fungus, Aspergillus aculeatus, J ANTIBIOT, 54(11), 2001, pp. 904-910
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
0021-8820 → ACNP
Volume
54
Issue
11
Year of publication
2001
Pages
904 - 910
Database
ISI
SICI code
0021-8820(200111)54:11<904:CANIOS>2.0.ZU;2-B
Abstract
A new squalene synthase (SSase) inhibitor, CJ-15,183 (I) was isolated from the fermentation broth of a fungus, Aspergillus aculeatus CL38916. The comp ound potently inhibited rat liver and Candida albicans microsomal SSases an d also inhibited the human enzyme. It also showed antifungal activities aga inst filamentous fungi and a yeast. The structure was determined to be an a liphatic tetracarboxylic acid compound consisting of an alkyl gamma -lacton e, malic acid and isocitric acid moieties by spectroscopic studies.