Bisabosquals, novel squalene synthase inhibitors - II. Physico-chemical properties and structure elucidation

Citation
K. Minagawa et al., Bisabosquals, novel squalene synthase inhibitors - II. Physico-chemical properties and structure elucidation, J ANTIBIOT, 54(11), 2001, pp. 896-903
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
0021-8820 → ACNP
Volume
54
Issue
11
Year of publication
2001
Pages
896 - 903
Database
ISI
SICI code
0021-8820(200111)54:11<896:BNSSI->2.0.ZU;2-3
Abstract
The squalene synthase inhibitor bisabosqual A was isolated from the culture broth of Stachybotrys sp. RF-7260, and its structure was determined on the basis of spectroscopic methods including detailed 2D NMR analyses. The str uctures of bisabosquals B, C and D isolated from Stachybotrys ruwenzoriensi s RF-6853 were determined by spectroscopic methods and chemical reactions. The absolute stereochemistry of bisabosquals A, B and D was determined by X -ray crystallographic analysis. They have novel cis-fused tetracyclic struc tures with a bisabolane-type sesquiterpene and phenol moieties.