K. Minagawa et al., Bisabosquals, novel squalene synthase inhibitors - II. Physico-chemical properties and structure elucidation, J ANTIBIOT, 54(11), 2001, pp. 896-903
The squalene synthase inhibitor bisabosqual A was isolated from the culture
broth of Stachybotrys sp. RF-7260, and its structure was determined on the
basis of spectroscopic methods including detailed 2D NMR analyses. The str
uctures of bisabosquals B, C and D isolated from Stachybotrys ruwenzoriensi
s RF-6853 were determined by spectroscopic methods and chemical reactions.
The absolute stereochemistry of bisabosquals A, B and D was determined by X
-ray crystallographic analysis. They have novel cis-fused tetracyclic struc
tures with a bisabolane-type sesquiterpene and phenol moieties.