Pharmacokinetics of cefcapene pivoxil and AS-924 in gastrectomized patients

Authors
Citation
M. Fujimoto, Pharmacokinetics of cefcapene pivoxil and AS-924 in gastrectomized patients, INT J ANT A, 18(5), 2001, pp. 489-494
Citations number
6
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Microbiology
Journal title
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
ISSN journal
0924-8579 → ACNP
Volume
18
Issue
5
Year of publication
2001
Pages
489 - 494
Database
ISI
SICI code
0924-8579(200111)18:5<489:POCPAA>2.0.ZU;2-C
Abstract
To investigate the effects of gastrectomy on the absorption of drugs, the b lood concentrations or the active moieties, cefcapene (CCAP) and ceftizoxim e (CTIZ), were determined in 36 gastrectomized patients after oral administ ration of cefcapene pivoxil (CCAP-PI) and AS-924, prodrug type cephem antib iotics with different solubility-profiles. In patients with gastrectomy, th e C-max and AUC for CCAP-PI whose solubility depended on the acidity of gas tric juice, were lower than in the controls; whereas those for AS-924 were comparable with values in the control group. The T-max was affected by the extent of gastrectomy; the T-max value was the lowest in patients who had u ndergone total gastrectomy Roux-Y, followed by Billroth It and Billroth I p rocedure of subtotal gastrectomy. These results indicate the need to select drugs and to instruct gastrectomized patients regarding dosage and adminis tration, taking the pharmacokinetics of drugs into consideration. (C) 2001 Published by Elsevier Science B.V. and International Society of Chemotherap y.