Effects of gastrointestinal stimulant and suppressant pretreatment on the pharmacokinetics of AS-924, a novel ester-type cephem antibiotic

Citation
A. Yanagawa et al., Effects of gastrointestinal stimulant and suppressant pretreatment on the pharmacokinetics of AS-924, a novel ester-type cephem antibiotic, INT J ANT A, 18(5), 2001, pp. 483-487
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Microbiology
Journal title
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
ISSN journal
0924-8579 → ACNP
Volume
18
Issue
5
Year of publication
2001
Pages
483 - 487
Database
ISI
SICI code
0924-8579(200111)18:5<483:EOGSAS>2.0.ZU;2-#
Abstract
The effects of pretreatment with the gastrointestinal stimulant domperidone and the suppressant scopolamine butylbromide on the absorption of AS-924, a novel prodrug-type cephem antibiotic, were investigated in six healthy ad ult male volunteers by a cross-over method. The T-max of ceftizoxime (CTIZ) , the active moiety of AS-924, was slightly prolonged by scopolamine butylb romide (T-max = 1.8 vs. 1.5 h for the group without pretreatment). However. there were no significant differences in pharmaco kinetic parameters inclu ding T-max cumulative urinary excretion rates of CTIZ and cumulative urinar y excretion rates of pivaloylcarnitine for 12 h after the dosing between th e pretreated and control groups. Domperidone did not affect the absorption of AS-924. (C) 2001 Published by Elsevier Science BN. and International Soc iety of Chemotherapy.