The effects of pretreatment with the gastrointestinal stimulant domperidone
and the suppressant scopolamine butylbromide on the absorption of AS-924,
a novel prodrug-type cephem antibiotic, were investigated in six healthy ad
ult male volunteers by a cross-over method. The T-max of ceftizoxime (CTIZ)
, the active moiety of AS-924, was slightly prolonged by scopolamine butylb
romide (T-max = 1.8 vs. 1.5 h for the group without pretreatment). However.
there were no significant differences in pharmaco kinetic parameters inclu
ding T-max cumulative urinary excretion rates of CTIZ and cumulative urinar
y excretion rates of pivaloylcarnitine for 12 h after the dosing between th
e pretreated and control groups. Domperidone did not affect the absorption
of AS-924. (C) 2001 Published by Elsevier Science BN. and International Soc
iety of Chemotherapy.