Effects of food intake and age on the pharmacokinetics of AS-924, a novel ester-type cephem antibiotic. Comparison with cefpodoxime proxetil

Totsuka, K Shimizu, K Mori, N Sugihara, T Sakai, A Yamaji, S Michisuji, Y Shinohara, Y Kubo, A Tokuoka, H

K. Totsuka et al., Effects of food intake and age on the pharmacokinetics of AS-924, a novel ester-type cephem antibiotic. Comparison with cefpodoxime proxetil, INT J ANT A, 18(5), 2001, pp. 463-469

12

INGLESE

Article

Microbiology

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

0924-8579 → ACNP

18

5

2001

463 - 469

ISI

0924-8579(200111)18:5<463:EOFIAA>2.0.ZU;2-G

The effects of food intake and age on intestinal absorption of AS-924. a no vel prodrug-type cephem antibiotic, were examined in 16 healthy adult volun teers (eight young volunteers and eight elderly volunteers) by the cross-ov er method, using cefpodoxime proxetil (CPOD-PR) as the control drug. The ga strointestinal absorption of AS-924 and CPOD-PR was increased slightly by f ood intake and the extent of increase was slightly greater after administra tion of CPOD-PR, The absorption of AS-924 was not affected by age, whereas intestinal absorption of CPOD-PR increased with age. In conclusion, these r esults confirmed that AS-924 has the unique characteristics as a novel prod rug and that its absorption is less likely to be affected by food intake an d age, (C) 2001 Published by Elsevier Science B.V. and International Societ y of Chemotherapy.