K. Totsuka et al., Effects of food intake and age on the pharmacokinetics of AS-924, a novel ester-type cephem antibiotic. Comparison with cefpodoxime proxetil, INT J ANT A, 18(5), 2001, pp. 463-469
The effects of food intake and age on intestinal absorption of AS-924. a no
vel prodrug-type cephem antibiotic, were examined in 16 healthy adult volun
teers (eight young volunteers and eight elderly volunteers) by the cross-ov
er method, using cefpodoxime proxetil (CPOD-PR) as the control drug. The ga
strointestinal absorption of AS-924 and CPOD-PR was increased slightly by f
ood intake and the extent of increase was slightly greater after administra
tion of CPOD-PR, The absorption of AS-924 was not affected by age, whereas
intestinal absorption of CPOD-PR increased with age. In conclusion, these r
esults confirmed that AS-924 has the unique characteristics as a novel prod
rug and that its absorption is less likely to be affected by food intake an
d age, (C) 2001 Published by Elsevier Science B.V. and International Societ
y of Chemotherapy.