Effects of adhesives and permeation enhancers on the skin permeation of captopril

Citation
Es. Park et al., Effects of adhesives and permeation enhancers on the skin permeation of captopril, DRUG DEV IN, 27(9), 2001, pp. 975-980
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
ISSN journal
0363-9045 → ACNP
Volume
27
Issue
9
Year of publication
2001
Pages
975 - 980
Database
ISI
SICI code
0363-9045(2001)27:9<975:EOAAPE>2.0.ZU;2-1
Abstract
To formulate a transdermal drug delivery system of captopril, monolithic ad hesive matrix type patches containing 20% captopril, different pressure-sen sitive adhesives, and various permeation enhancers were prepared using a la bcoater. The effects of the adhesives and permeation enhancers on skin perm eation of captopril from the prepared patches were evaluated using Franz di ffusion cells fitted with excised rat skins. The permeation rate of the dru g through the excised skin was dependent on the type of polyacrylate copoly mers studied. Fatty alcohols resulted in a pronounced enhancing effect on t he skin permeation of captopril, while dimethyl sulfoxide, N-methyl-2-pyrro lidone, oleic acid, Transcutol, and polysorbate 20 showed no significant en hancing effect. The permeation-enhancing effect of the fatty alcohols reach ed the maximum at the level of 10%. Based on these results, a captopril pat ch may be developed with further optimization.