Decrease of effectivity of 'competing' synaptic input requires protein synthesis

Citation
P. Balaban et O. Maksimova, Decrease of effectivity of 'competing' synaptic input requires protein synthesis, BRAIN RES, 919(2), 2001, pp. 318-321
Citations number
9
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
0006-8993 → ACNP
Volume
919
Issue
2
Year of publication
2001
Pages
318 - 321
Database
ISI
SICI code
0006-8993(20011123)919:2<318:DOEO'S>2.0.ZU;2-T
Abstract
We describe that tetanus-induced long-term increase of the response amplitu de in one input to an identified neuron is accompanied by a decrease, of sy naptic responses in another, non-tetanized input. Induction of the decrease of responses in non-tetanized inputs was prevented by bath application of protein synthesis blockers (anisomycin or cycloheximide). The decrease of r esponses also did not occur in experiments when tetanization was substitute d by short-term serotonin applications or extracellular stimulation of sero tonergic cells known to potentiate investigated synaptic inputs. The result s suggest that the heterosynaptically evoked decrease of synaptic response amplitude may be due to involvement of postsynaptic protein synthesis-depen dent mechanisms. (C) 2001 Elsevier Science B.V. All rights reserved.