Glycine receptor-mediated inhibition of dopamine and non-dopamine neurons of the rat ventral tegmental area in vitro

Citation
F. Zheng et Sw. Johnson, Glycine receptor-mediated inhibition of dopamine and non-dopamine neurons of the rat ventral tegmental area in vitro, BRAIN RES, 919(2), 2001, pp. 313-317
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
0006-8993 → ACNP
Volume
919
Issue
2
Year of publication
2001
Pages
313 - 317
Database
ISI
SICI code
0006-8993(20011123)919:2<313:GRIODA>2.0.ZU;2-M
Abstract
Dopaminergic and non-dopaminergic neurons of the ventral tegmental area (VT A) were recorded intracellularly in slices of rat midbrain. Glycine (0.1-3 mM)caused a strychnine-sensitive and chloride-dependent reduction in membra ne input resistance in both types of neuron. However, glycine also reduced the frequency of spontaneous bicuculline-sensitive inhibitory postsynaptic potentials (IPSPS) when recorded in dopaminergic cells. We conclude that gl ycine inhibits both types of VTA neuron by activating a strychnine-sensitiv e chloride conductance, Our data also raise the possibility that glycine co uld increase dopamine output from the VTA by a mechanism of disinhibition. (C) 2001 Elsevier Science B.V. All rights reserved.